Know what’s inside:
In-Vivo DMPK
Flexibility & Speed
Flexibility in study design and meeting demanding time lines is the strength of the GBA Group In-Vivo team. We offer DMPK studies in mice, rats, guinea pigs and hamsters. The GBA Group offers include complete workflow studies (in-life part, bioanalysis and PK evaluation, biomarker assessment ). Non-GLP bioanalysis and GLP bioanalysis of samples from all animal species can be performed.
Your direct contact
Dr. Daniel Da Costa
BD Director Preclinical Services Europe
Species
- Rodents
Application Routes
- Intravenous (bolus or infusion)
- Oral (liquid, capsules)
- Intraperitoneal
- Subcutaneous (incl. osmotic - minipumps)
- Intramuscular
- Intradermal
- Intranasal
- Topical
- Intravitreal
- Intraportal
- Single, repeated and cassette dosing
Exploratory PK Studies
- Microsampling/snapshot PK
- Cassette dosing
- Major metabolites
Surgical Methods
- Cannulation (Rat)
- vena jugularis (neck or head attachment)
- portal vein* (e.g. for evaluation of first-pass effect)
- bile duct* (e.g. for evaluation of entero-hepatic circulation)
- Bile duct ligation (Rat)
- Castration
*animal surgery is conducted at the provider of rats and mice.
Sampling Methods
- Jugular catheter
- Tail vein or artery
- Sublingual vein
- Facial vein
- Plexus retrobulbaris
- Heart puncture (terminal)
- Microsampling
- Tissue perfusion
- Metabolic cage
Sample Types
- Whole blood, plasma, dried blood spots
- Excreta
- urine
- faeces
- bile
- Bronchioalveolare lavage fluid
- Cerebrospinal fluid
- Tissues/organs
Biomarkers
- All Markers that can be quantified in biological matrices by validated immuno-assay or LC-MS-methods
- Sample processing for histology
- Haematology
Full PK Studies
- Dose proportionality
- Organ distribution, excretion, mass - balance
- Metabolite identification
- First pass effect
Ex vivo Investigation
- Brain slice method
All experimental procedures are approved by and conducted in accordance with the regulations of the local Animal Welfare authorities. The GBA Group in vivo department is frequently audited by clients with positive results.
